@CellBiophysics @DawsonStemCell
Dawson Cancer Biophysics Lab
Studying outlier populations of invasive cancer cells and mechanisms they use to evade treatment
Signed in as:
filler@godaddy.com
@CellBiophysics @DawsonStemCell
Studying outlier populations of invasive cancer cells and mechanisms they use to evade treatment
Dawsonlab receives new R01 funding from National Cancer Institute for ovarian cancer research!
Dysregulated lipid metabolism is a hallmark of epithelial ovarian cancer, which is associated with widespread and rapid metastasis throughout the lipid-rich abdominal cavity. A key fact is that epithelial ovarian cancer cells can metabolically reprogram themselves to use other energy sources, such as lipids and fat cells in the abdominal cavity, to sustain their incredibly fast growth—metabolic changes that also help them survive after chemotherapy.
This grant will investigate the hypothesis that EOC cells store energy in intracellular lipid droplets and under metabolic stress use this stored energy to fuel growth and invasive cell migration; this hypothesis will be explored using a novel 3D culture model to track metabolic changes in chemoresistant EOC cells as well as to study their lipid droplet metabolism and autophagy.
https://reporter.nih.gov/search/c-FjwYfHDECVT3W5G2c8zg/project-details/10522428
Congratulations to the Class of 2022!
Dr. Carolina Mejia Pena and Dr. Amy H. Lee graduate with their PhDs in Molecular and Cell Biology and Biochemistry (MCB) and Biomedical Engineering (BME), respectively.
Dr. Lee continues research as MIT-HMS postdoc in Bob Langer's lab and Dr. Mejia Pena continues research as postdoc in Dawson Lab.
Matthew Perricone receives the 2022 Elizabeth Leduc Prize in Cell and Molecular Biology and graduates with his undergraduate degree in Biology.
Matt continues research as a PhD student at U Michigan.
Dr. Carolina Mejia Pena and Dr. Amy H. Lee celebrate their thesis defenses
Dr. Carolina Mejia Pena defended 4/22/2022
Dr. Amy H. Lee defended 4/27/2022
Celebration 5/3/2022, 3-5 pm BMC 3rd flr atrium
New Exosome Review
The Role of Exosome Heterogeneity in Epithelial Ovarian Cancer
by Amy Lee, Ivy Koh, and Michelle Dawson
New Ovarian Cancer Review
Comparing the Secretomes of Chemorefractory and Chemoresistant Ovarian Cancer Cell Populations
by Amy Lee, Carolina Mejia Pena, and Michelle Dawson
PNAS Paper
Vimentin Filaments Drive Migratory Persistence in Polyploidal Cancer Cells
Outstanding Thesis Award
Botai Xuan wins Joukowsky Outstanding Dissertation Award for the 2020-2021
Dr. Ghosh Promoted
Deepraj is promoted to research assistant professor of biomedical sciences
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