@CellBiophysics @DawsonStemCell
Dawson Cancer Biophysics Lab
Studying outlier populations of invasive cancer cells and mechanisms they use to evade treatment
Updates
New Paper Alert!
2023 NESS Presentation Award
Physics of Cancer Book!
This paper published in Reproductive Sciences looks at differences in uterine fibroid and myometrial cell mechanics
DOI: 10.1007/s43032-023-01267-z
Physics of Cancer Book!
2023 NESS Presentation Award
Physics of Cancer Book!
Please see our new book, "Engineering and Physical Approaches to Cancer."
2023 NESS Presentation Award
2023 NESS Presentation Award
2023 NESS Presentation Award
Congratulations to Ivy Koh for winning the Dana-Farber / Harvard Cancer Center Award for the best oral presentation of cancer research at the 2023 New England Science Symposium.
New paper!
New Funding!
2023 NESS Presentation Award
Congratulations to Dr. Amy Lee, Dr. Deepraj Ghosh, and Ivy Koh for their new paper in Aging.
Lee AH, Ghosh D, Koh IL, Dawson MR. Senescence-associated exosomes transfer miRNA-induced fibrosis to neighboring cells. Aging (Albany NY). 2023 Feb 23; . https://doi.org/10.18632/aging.204539
[Epub ahead of print]
New Funding!
New Funding!
New Funding!
Dawsonlab receives new R01 funding from National Cancer Institute for ovarian cancer research!
This grant will investigate the hypothesis that EOC cells store energy in intracellular lipid droplets and under metabolic stress use this stored energy to fuel growth and invasive cell migration; this hypothesis will be explored using a novel 3D
Dawsonlab receives new R01 funding from National Cancer Institute for ovarian cancer research!
This grant will investigate the hypothesis that EOC cells store energy in intracellular lipid droplets and under metabolic stress use this stored energy to fuel growth and invasive cell migration; this hypothesis will be explored using a novel 3D culture model to track metabolic changes in chemoresistant EOC cells as well as to study their lipid droplet metabolism and autophagy.
https://reporter.nih.gov/search/c-FjwYfHDECVT3W5G2c8zg/project-details/10522428
New Funding!
New Funding!
Congratulations to the Class of 2022!
Dr. Carolina Mejia Pena and Dr. Amy H. Lee graduate with their PhDs in Molecular and Cell Biology and Biochemistry (MCB) and Biomedical Engineering (BME), respectively.
Dr. Lee continues research as MIT-HMS postdoc in Bob Langer's lab and Dr. Mejia Pena continues research as postdoc in Dawson Lab.
Matthe
Congratulations to the Class of 2022!
Dr. Carolina Mejia Pena and Dr. Amy H. Lee graduate with their PhDs in Molecular and Cell Biology and Biochemistry (MCB) and Biomedical Engineering (BME), respectively.
Dr. Lee continues research as MIT-HMS postdoc in Bob Langer's lab and Dr. Mejia Pena continues research as postdoc in Dawson Lab.
Matthew Perricone receives the 2022 Elizabeth Leduc Prize in Cell and Molecular Biology and graduates with his undergraduate degree in Biology.
Matt continues research as a PhD student at U Michigan.
Completed Dissertations!
New Ovarian Cancer Review
Completed Dissertations!
Dr. Carolina Mejia Pena and Dr. Amy H. Lee celebrate their thesis defenses
Dr. Carolina Mejia Pena defended 4/22/2022
Dr. Amy H. Lee defended 4/27/2022
Celebration 5/3/2022, 3-5 pm BMC 3rd flr atrium
New Exosome Review
New Ovarian Cancer Review
Completed Dissertations!
The Role of Exosome Heterogeneity in Epithelial Ovarian Cancer
This review provides an overview on exosome structure and biogenesis and summarizes recent studies on ovarian cancer exosomes, exosome mediated interactions in the tumor microenvironment, and exosome heterogeneity.
by Amy Lee, Ivy Koh, and Michelle Dawson
New Ovarian Cancer Review
New Ovarian Cancer Review
New Ovarian Cancer Review
Congratulations to Amy Lee and Carolina Mejia Pena for their new review article titled, 'Comparing the Secretomes of Chemorefractory and Chemoresistant Ovarian Cancer Cell Populations.'
This review covers feedback loops that transfer resistance between chemoresistant EOC cells and normal bystander cells and cancer cells.
PNAS Paper
Outstanding Thesis Award
New Ovarian Cancer Review
Vimentin Filaments Drive Migratory Persistence in Polyploidal Cancer Cells
Although the presence of polyploidal cells in solid tumors has been correlated with worse patient outcomes, there is a lack of understanding of the underlying biophysical mechanisms that drive their abnormal behavior. Here we show that vimentin is key to their migratory persistence.
Outstanding Thesis Award
Outstanding Thesis Award
Outstanding Thesis Award
Botai Xuan wins Joukowsky Outstanding Dissertation Award for the 2020-2021.
Xuan’s dissertation titled, Unraveling the Contributions of Polyploidal Giant Cancer Cells in Cancer Progression, focused on an understudied population of giant cancer cells that contributes to disease progression and chemoresistance.
Dr. Ghosh Promoted
Outstanding Thesis Award
Outstanding Thesis Award
Deepraj Ghosh was promoted to research assistant professor of biomedical sciences. Congratulations to DG!