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@CellBiophysics @DawsonStemCell

Dawson Cancer Biophysics Lab

Dawson Cancer Biophysics LabDawson Cancer Biophysics LabDawson Cancer Biophysics Lab

Studying outlier populations of invasive cancer cells and mechanisms they use to evade treatment

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Updates

New paper!


Congratulations to Dr. Amy Lee, Dr. Deepraj Ghosh, and Ivy Koh for their new paper in Aging.


Lee AH, Ghosh D, Koh IL, Dawson MR. Senescence-associated exosomes transfer miRNA-induced fibrosis to neighboring cells. Aging (Albany NY). 2023 Feb 23; . https://doi.org/10.18632/aging.204539 

[Epub ahead of print] 


Dawsonlab receives new R01 funding from National Cancer Institute for ovarian cancer research!


Dysregulated lipid metabolism is a hallmark of epithelial ovarian cancer, which is associated with widespread and rapid metastasis throughout the lipid-rich abdominal cavity. A key fact is that epithelial ovarian cancer cells can metabolically reprogram themselves to use other energy sources, such as lipids and fat cells in the abdominal cavity, to sustain their incredibly fast growth—metabolic changes that also help them survive after chemotherapy. 


This grant will investigate the hypothesis that EOC cells store energy in intracellular lipid droplets and under metabolic stress use this stored energy to fuel growth and invasive cell migration; this hypothesis will be explored using a novel 3D culture model to track metabolic changes in chemoresistant EOC cells as well as to study their lipid droplet metabolism and autophagy.


https://reporter.nih.gov/search/c-FjwYfHDECVT3W5G2c8zg/project-details/10522428


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Congratulations to the Class of 2022!


Dr. Carolina Mejia Pena and Dr. Amy H. Lee graduate with their PhDs in Molecular and Cell Biology and Biochemistry (MCB) and Biomedical Engineering (BME), respectively.


Dr. Lee continues research as MIT-HMS postdoc in Bob Langer's lab and Dr. Mejia Pena continues research as postdoc in Dawson Lab.


Matthew Perricone receives the 2022  Elizabeth Leduc Prize in  Cell and  Molecular  Biology and graduates with his undergraduate degree in Biology.


Matt continues research as a PhD student at U Michigan.


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Dr. Carolina Mejia Pena and Dr. Amy H. Lee celebrate their thesis defenses


Dr. Carolina Mejia Pena defended 4/22/2022

Dr. Amy H. Lee defended 4/27/2022


Celebration 5/3/2022, 3-5 pm BMC 3rd flr atrium    


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New Exosome Review


The Role of Exosome Heterogeneity in Epithelial Ovarian Cancer    


by Amy Lee, Ivy Koh, and Michelle Dawson


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New Ovarian Cancer Review


Comparing the Secretomes of Chemorefractory and Chemoresistant Ovarian Cancer Cell Populations


by Amy Lee, Carolina Mejia Pena, and Michelle Dawson

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PNAS Paper


Vimentin Filaments Drive Migratory Persistence in Polyploidal Cancer Cells 

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Outstanding Thesis Award


Botai Xuan wins Joukowsky Outstanding Dissertation Award for the 2020-2021

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Dr. Ghosh Promoted


Deepraj is promoted to research assistant professor of biomedical sciences

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  • Cell & Molecular Biology
  • Biophysics & Biomechanics
  • Quantitative Imaging

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